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Updated: May 21, 2026

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions
Published on: August 11, 2016
[Degeneration and regeneration of the peripheral nerve]
1Univerzita Karlova v Praze, 3. lékarská fakulta a FN Královské Vinohrady, Neurochirurgická klinika, Praha. radek.kaiser@fnkv.cz
Abstract:
The peripheral nerve's degeneration and regeneration after its injury was described by Waller in 1850. The distal stump and small part of the proximal part of the transected fibre disintegrate. Proliferating Schwann cells create the band of Büngner for the guiding of the regrowing axon. Even if the suture of the nerve is quickly and well performed, the reinervation is never absolute. Regrowing axons can grow into wrong endoneurial tubes or outside the area of the suture and long-lasting denervation leads to progressive atrophy of the target organs. In the future, the neurotrophic factors might improve the outcome of the reinervation.
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