Electrospun fibrous scaffolds for bone and cartilage tissue generation: recent progress and future developments

Area of Science:

• Tissue Engineering
• Biomaterials Science
• Regenerative Medicine

Background:

• Tissue engineering seeks to accelerate natural healing processes for bone and cartilage regeneration.
• Electrospinning is a key nano-/microtechnique for creating biomimetic fibrous scaffolds.

Purpose of the Study:

• To review recent advancements in electrospinning for bone and cartilage tissue engineering.
• To highlight novel fabrication methods and materials for enhanced regenerative constructs.

Main Methods:

• Review of literature on electrospinning-based technologies for tissue regeneration.
• Focus on multimaterial electrospinning and electrospraying techniques.
• Analysis of incorporating morphogenetic/bioactive factors and novel nanomaterials.

Main Results:

• Electrospinning offers versatile fabrication of fibrous constructs for tissue regeneration.
• Multimaterial electrospinning and electrospraying enable complex scaffold design.
• Incorporation of bioactive factors and biomimetic nanomaterials improves regenerative potential.

Conclusions:

• Electrospinning-based technologies are advancing bone and cartilage regeneration.
• Combining techniques and advanced materials shows significant promise for future therapies.
• Further research into biologically inspired nanomaterials is crucial for optimizing tissue-engineered constructs.