Pediatric infectious disease: unusual head and neck infections

Kathryn S Moffett1

  • 1Pediatric Infectious Diseases, West Virginia University, HSC-9214, Morgantown, WV 26506-9214, USA. kmoffett@hsc.wvu.edu

Insights

This review covers common and rare pediatric head and neck infections, including PFAPA syndrome and Lemierre syndrome. It also discusses new pediatric vaccines for preventing oropharyngeal cancers.

Area of Science:

  • Pediatric Infectious Diseases
  • Otolaryngology
  • Vaccinology

Background:

  • Head and neck infections are prevalent in pediatric populations, contributing to significant antibiotic use.
  • Diverse infectious etiologies, from common to rare, affect infants, children, and adolescents.
  • Emerging vaccines offer potential for preventing oropharyngeal cancers.

Purpose of the Study:

  • To review common and unusual infectious diseases of the head and neck in children.
  • To highlight specific conditions like PFAPA syndrome, Lemierre Syndrome, and various adenitis types.
  • To discuss novel pediatric vaccines targeting oropharyngeal cancer prevention.

Main Methods:

  • Comprehensive literature review of pediatric head and neck infections.
  • Inclusion of common, diverse, and rare infectious disease case studies.
  • Analysis of current and emerging pediatric vaccination strategies.

Main Results:

  • Identification of key infectious agents and syndromes affecting the pediatric head and neck.
  • Detailed description of PFAPA syndrome, Lemierre Syndrome, Arcanobacterium infections, and adenitis.
  • Overview of the first available pediatric vaccines for oropharyngeal cancer prevention.

Conclusions:

  • Effective management of pediatric head and neck infections requires awareness of diverse etiologies.
  • Antibiotic stewardship is crucial given the frequency of these infections.
  • New vaccines represent a significant advancement in pediatric oncology and preventative care.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...