Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lymphoproliferation stimulating activity in serum].

A Moretta1, A Valtorta, I Biscaldi

  • 1Clinica Pediatrica, Policlinico S. Matteo, Università di Pavia.

Medicina (Florence, Italy)
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

Physical review letters·2023
Same author

Recent Advances in Human Natural Killer Cells.

International archives of allergy and immunology·2021
Same author

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance.

Cellular and molecular life sciences : CMLS·2021
Same author

Impact of the spatial structure of the hydraulic conductivity field on vorticity in three-dimensional flows.

Proceedings. Mathematical, physical, and engineering sciences·2016
Same journal

[Infectious diseases].

Medicina (Florence, Italy)·1990
Same journal

[The human genome project: reflections of an expert].

Medicina (Florence, Italy)·1990
Same journal

[Decrease in notifications of AIDS dementia complex in 1989-1990 in Italy: possible role of the early treatment with zidovudine].

Medicina (Florence, Italy)·1990
Same journal

[Clinical usefulness of a new echocardiographic window: the transesophageal approach].

Medicina (Florence, Italy)·1990
Same journal

[Skin disease in Basedow's disease].

Medicina (Florence, Italy)·1990
Same journal

[Prognostic factors in Raynaud's phenomenon: usefulness of antinuclear antibodies and of periungual capillaroscopy].

Medicina (Florence, Italy)·1990
See all related articles

Serum growth-promoting activity was analyzed in adults and infants using thymidine uptake bioassays. Key growth-promoting fractions were identified, with infants showing higher activity, suggesting a link to rapid growth.

Area of Science:

  • Immunology
  • Biochemistry
  • Pediatrics

Background:

  • Serum contains growth-promoting factors crucial for cellular proliferation.
  • Understanding these factors is vital for studying growth and development, especially in infants.

Purpose of the Study:

  • To characterize and compare serum growth-promoting activity in normal adults and infants.
  • To identify specific serum fractions responsible for stimulating lymphocyte proliferation.

Main Methods:

  • Gel filtration chromatography was used to separate serum components.
  • Bioassays measured the capacity of serum fractions to stimulate tritiated thymidine (3H-TdR) uptake in activated lymphocytes.

Main Results:

  • Three distinct molecular weight fractions (1500-2500 Kd, 28-42 Kd, 1.3-1.9 Kd) consistently showed growth-promoting activity in both adults and infants.

Related Experiment Videos

  • Infants exhibited higher 3H-TdR uptake compared to adults across these active fractions.

    • Conclusions:

    • Serum growth-promoting activity is present in specific molecular weight ranges in both adults and infants.
    • Higher activity in infants suggests a correlation with rapid growth phases in early life.