Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Venules01:08

Venules

Venules are an integral part of the microscopic circulatory system that bridges the gap between capillaries and veins.
Venules are much smaller in diameter compared to their larger counterparts, the veins. They are generally 8 to 100 micrometers in diameter, significantly smaller than the size of veins. The walls of venules are thin, consisting of the endothelium, a thin layer of connective tissue, and occasionally a few smooth muscle cells. This structural simplicity is a stark contrast...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mycophenolate mofetil as a steroid-sparing agent in oral mucous membrane pemphigoid: A retrospective review.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

A Structured Approach for the Management of Orodynia (Burning Mouth Syndrome).

Cutis·2024
Same author

Predictors of hypothyroidism amongst dermatomyositis in-patients and an evaluation of financial and demographic differences based on thyroid status.

Archives of dermatological research·2024
Same author

Stressors in Atopic Dermatitis.

Advances in experimental medicine and biology·2024
Same author

Should systemic corticosteroids be relatively contraindicated in granuloma annulare?

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Evaluation of pentoxifylline in the treatment of necrobiosis lipoidica: outcomes in 10 patients.

International journal of dermatology·2024
Same journal

Increased Risk of Cutaneous T-Cell Lymphoma Development after Dupilumab Use for Atopic Dermatitis.

Dermatologic therapy·2024
Same journal

Correction to "Adjuvant PD-1 inhibitor versus high-dose interferon α-2b for Chinese patients with cutaneous and acral melanoma: A retrospective cohort analysis".

Dermatologic therapy·2022
Same journal

A case of erythema nodosum concomitant with ulcerative colitis relieved by tofacitinib.

Dermatologic therapy·2022
Same journal

A case report of vitiligo following toripalimab therapy for a patient with metastatic melanoma.

Dermatologic therapy·2022
Same journal

High versus low dose oral isotretinoin in the treatment of cutaneous and genital warts.

Dermatologic therapy·2022
Same journal

Evaluation of the efficacy and relapse rates of treatment protocols for moderate acne using isotretinoin based on the global acne grading system: Randomized, controlled, comparative study.

Dermatologic therapy·2022
See all related articles

Related Experiment Video

Updated: May 21, 2026

Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies
08:49

Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies

Published on: May 23, 2025

Small-vessel vasculitis.

Megan A Kinney1, Joseph L Jorizzo

  • 1Department of Dermatology,Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27101, USA. mkinney@wakehealth.edu

Dermatologic Therapy
|June 30, 2012
PubMed
Summary
This summary is machine-generated.

Small-vessel vasculitis involves blood vessel inflammation, primarily affecting the skin. Proper diagnosis and management are crucial for addressing potential systemic issues and ensuring effective patient care.

More Related Videos

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity
07:00

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity

Published on: April 28, 2012

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
10:35

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Published on: January 12, 2020

Related Experiment Videos

Last Updated: May 21, 2026

Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies
08:49

Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies

Published on: May 23, 2025

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity
07:00

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity

Published on: April 28, 2012

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
10:35

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Published on: January 12, 2020

Area of Science:

  • Rheumatology
  • Dermatology
  • Pathology

Background:

  • Vasculitis is defined as inflammation of the blood vessel wall.
  • Small-vessel vasculitides specifically impact post-capillary venules, frequently manifesting in the skin.
  • Accurate classification of small-vessel vasculitides is essential due to potential systemic involvement and varied treatment needs.

Purpose of the Study:

  • To outline the diagnostic and management principles for small-vessel vasculitis.
  • To emphasize the importance of identifying specific types of small-vessel vasculitides.
  • To highlight the need for comprehensive patient evaluation beyond skin manifestations.

Main Methods:

  • Diagnostic evaluation involves skin biopsy to confirm inflammation and identify the specific type of vasculitis.
  • Assessment includes determining the extent of the disease and investigating potential underlying causes (etiology).
  • Management strategies focus on supportive care, addressing triggers, and treating underlying conditions.

Main Results:

  • Small-vessel vasculitis requires a multi-faceted approach combining diagnostic procedures and etiological investigation.
  • Treatment is tailored based on the severity of skin lesions and the presence of systemic involvement.
  • Early and accurate diagnosis is key to preventing complications and improving patient outcomes.

Conclusions:

  • Effective management of small-vessel vasculitis necessitates a thorough diagnostic workup, including skin biopsy and etiological assessment.
  • Treatment plans must be individualized, considering both cutaneous and systemic disease activity.
  • Understanding the distinct types of small-vessel vasculitides guides appropriate patient evaluation and care.