Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation01:38

Inflammation

Overview
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study.

Thrombosis research·2024
Same author

Hemostatic factor levels and cognitive decline in older adults: The Cardiovascular Health Study.

Journal of thrombosis and haemostasis : JTH·2021
Same author

C-reactive protein and risk of cognitive decline: The REGARDS study.

PloS one·2020
Same author

Relation of Plasma Renin Activity to Subclinical Peripheral and Coronary Artery Disease (from the Multiethnic Study of Atherosclerosis).

The American journal of cardiology·2020
Same author

Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.

The journals of gerontology. Series A, Biological sciences and medical sciences·2019
Same author

C-reactive protein and stroke risk in blacks and whites: The REasons for Geographic And Racial Differences in Stroke cohort.

American heart journal·2019
Same journal

Cannabis and Cannabidiol, GLP-1 Receptors, and Autophagy: The Burgeoning Link Between Cognitive Neurodegeneration With Alzheimer's Disease and Metabolic Disorders.

Discovery medicine·2026
Same journal

The Urgent Need to Assess and Prevent the Deposits of Microplastics and Nanoplastics in Our Brain.

Discovery medicine·2025
Same journal

Bridging the Translational Gap: Prioritizing the Spontaneous Canine Osteoarthritis Model for Preclinical Studies.

Discovery medicine·2025
Same journal

Harnessing the Power of Chlorogenic Acid: Inhibiting IL-2-Mediated Treg Upregulation to Combat Post-Traumatic Osteomyelitis.

Discovery medicine·2025
Same journal

The Relationship of <i>MAPK10P</i> Gene Polymorphism With P-Wave Peak Time and P-Wave Dispersion in Elderly Patients With Paroxysmal Atrial Fibrillation.

Discovery medicine·2025
Same journal

Curcumin Attenuates PD-L1-Positive Neutrophil-Induced T-Lymphocyte Apoptosis and Alleviates Lung Injury During Sepsis in Rats.

Discovery medicine·2025
See all related articles

Related Experiment Video

Updated: May 21, 2026

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

Inflammation in aging: cause, effect, or both?

Nancy S Jenny1

  • 1Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA. nancy.jenny@med.uvm.edu

Discovery Medicine
|June 30, 2012
PubMed
Summary
This summary is machine-generated.

Aging involves progressive degeneration linked to chronic inflammation. Research explores theories like redox stress and immunosenescence, with Human Immunodeficiency Virus (HIV) offering insights into premature aging. Environmental factors also play a role.

More Related Videos

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
09:01

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Gerontology and immunology, focusing on the biological processes of aging and the immune system's role.

Background:

  • Aging is a complex degenerative process intrinsically linked with chronic inflammation, though the precise cause-and-effect relationship remains unclear.
  • Multiple theories, including redox stress, mitochondrial damage, immunosenescence, endocrinosenescence, epigenetic modifications, and age-related diseases, attempt to explain inflammation's role in aging.
  • Human Immunodeficiency Virus (HIV)-infected individuals exhibit premature aging, suggesting a potential model for understanding inflammation's impact on aging.

Purpose of the Study:

  • To explore the intricate relationship between chronic inflammation and the aging process.
  • To review existing theories on the role of inflammation in aging.
  • To investigate how Human Immunodeficiency Virus (HIV) infection and environmental factors may inform our understanding of aging and inflammation.

Main Methods:

  • Literature review of theories on aging and inflammation.
  • Analysis of the aging phenomenon in Human Immunodeficiency Virus (HIV)-infected patients.
  • Consideration of environmental and lifestyle factors influencing inflammation and aging.

Main Results:

  • No single theory fully explains aging; multiple intertwined processes involving inflammation are likely involved.
  • Human Immunodeficiency Virus (HIV) infection presents a model of premature aging, highlighting the connection between inflammation and accelerated aging.
  • Environmental and lifestyle factors can modulate inflammatory responses and age-related dysfunction.

Conclusions:

  • Aging is a multifactorial process deeply connected to chronic inflammation.
  • Understanding inflammation in aging may be advanced by studying conditions like HIV infection.
  • Modulating environmental and lifestyle factors could potentially influence inflammation and slow age-related decline.