Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uric Acid and Chronic Kidney Disease.

Kidney medicine·2026
Same author

Unemployment and Inability to Work: A Continued Worldwide Challenge for People Receiving Dialysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Hospital Readmissions in People with CKD: Moving a Stubborn Needle.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

KDOQI US Commentary on the KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Correction to: Tenapanor as Therapy for Hyperphosphatemia in Maintenance Dialysis Patients: Results from the OPTIMIZE Study.

Kidney360·2026
Same author

Composite Primary Outcomes in Nephrology Clinical Trials.

Kidney medicine·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
Same journal

Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

Kidney international·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

A physician's perseverance uncovers problems in a key nephrology study.

Steven Fishbane, Jay B Wish

    Kidney International
    |June 30, 2012
    PubMed
    Summary
    This summary is machine-generated.

    The Normal Hematocrit Cardiac Trial showed erythropoietin analog treatment wasn't a cure-all. A re-analysis revealed published results misrepresented the study's findings, impacting clinical practice.

    More Related Videos

    Ole Isacson: Development of New Therapies for Parkinson's Disease
    23:53

    Ole Isacson: Development of New Therapies for Parkinson's Disease

    Published on: April 29, 2007

    Related Experiment Videos

    Last Updated: May 21, 2026

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
    05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Ole Isacson: Development of New Therapies for Parkinson's Disease
    23:53

    Ole Isacson: Development of New Therapies for Parkinson's Disease

    Published on: April 29, 2007

    Area of Science:

    • Cardiology
    • Nephrology
    • Hematology

    Background:

    • The Normal Hematocrit Cardiac Trial (NHCT) evaluated erythropoietin analogs for anemia in patients with chronic kidney disease.
    • The study aimed to determine if normalizing hematocrit levels improved cardiac outcomes.
    • NHCT results influenced clinical guidelines and treatment decisions regarding erythropoietin therapy.

    Purpose of the Study:

    • To critically re-evaluate the published findings of the Normal Hematocrit Cardiac Trial.
    • To assess the accuracy and completeness of the original study's reported results.
    • To discuss the implications of potential data misrepresentation on clinical practice and guideline development.

    Main Methods:

    • Re-analysis of the Normal Hematocrit Cardiac Trial data.
    • Comparison of published results with actual study data.
    • Literature review of evidence synthesis and guideline development influenced by NHCT.

    Main Results:

    • Published results of the NHCT may not fully or accurately represent the study's actual findings.
    • Discrepancies identified could alter the interpretation of erythropoietin analog efficacy.
    • The study's significant impact on treatment decisions warrants a closer examination of its reported outcomes.

    Conclusions:

    • The Normal Hematocrit Cardiac Trial's published data requires careful scrutiny due to potential inaccuracies.
    • Misrepresentation of study results can have far-reaching consequences on patient care and medical guidelines.
    • Recommendations are proposed to enhance transparency and accuracy in clinical trial reporting to prevent future occurrences.