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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures
Vamsi V Nagineni1, Andrew R James, Marjan Alimi
1Brain and Spine Center, Department of Neurological Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Spine
|June 30, 2012
Summary
Silicate-substituted calcium phosphate (Si-CaP) demonstrated high spinal fusion rates (90%) and improved clinical outcomes in 108 patients. This synthetic ceramic is a viable alternative to autogenous bone grafts for spinal arthrodesis.
Area of Science:
- Orthopedics
- Biomaterials Science
- Spinal Surgery
Background:
- Silicate-substituted calcium phosphate (Si-CaP) is a synthetic ceramic engineered for enhanced osteoinduction and osteoconduction.
- It serves as a bone graft substitute in orthopedic and spinal fusion procedures.
Purpose of the Study:
- To evaluate the clinical and radiographical efficacy of Si-CaP in spinal fusion surgeries.
- To assess Si-CaP as an alternative to autogenous bone graft.
Main Methods:
- Retrospective analysis of 108 patients (204 spinal levels) undergoing various spinal fusion procedures.
- Si-CaP used as a bone extender without additional bone graft materials.
- Clinical outcomes assessed via VAS, Oswestry Disability Index, and Neck Disability Index.
- Radiographical fusion confirmed by CT imaging.
Main Results:
- 90% overall radiographical fusion rate at 12-month follow-up.
- Highest fusion rates observed in cervical spine (97%), followed by thoracic (86%) and lumbar (81%).
- Significant improvements noted in all clinical outcome measures.
- No instrumentation loosening, infection, or nonunion complications reported.
Conclusions:
- Si-CaP is a safe and effective alternative to autogenous bone graft in spinal arthrodesis.
- High bony fusion levels achieved with Si-CaP across diverse spinal surgical techniques.
