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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 20, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

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Published on: May 25, 2020

Biomarkers in primary open angle glaucoma.

Haris Kokotas1, Christos Kroupis, Dimitrios Chiras

  • 1Department of Genetics, Institute of Child Health , Aghia Sophia Children's Hospital, Athens, Greece. hkokotas@yahoo.gr

Clinical Chemistry and Laboratory Medicine
|June 30, 2012
PubMed
Summary

This study reviews non-genetic molecular markers linked to Primary Open Angle Glaucoma (POAG), a major cause of blindness. It focuses on markers needing further validation to understand POAG progression and potential treatments.

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

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Published on: June 3, 2018

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Glaucoma is a leading cause of irreversible blindness globally.
  • Characterized by optic nerve damage and visual field loss, often linked to elevated intraocular pressure (IOP).
  • Primary Open Angle Glaucoma (POAG) is a progressive, multifactorial neuropathy affecting the optic nerve with open anterior chamber angles.

Purpose of the Study:

  • To summarize current knowledge on non-genetic molecular markers associated with POAG.
  • To identify markers that have been predicted but not yet validated in relation to POAG.
  • To consolidate information for future research into POAG pathogenesis and treatment.

Main Methods:

  • Literature review of existing studies on POAG.
  • Identification and categorization of non-genetic molecular markers.
  • Analysis of the predictive association and validation status of these markers.

Main Results:

  • Several non-genetic molecular markers have been implicated in POAG development and progression.
  • A significant number of these markers show predicted associations but lack robust clinical validation.
  • The review highlights gaps in current research regarding these specific markers.

Conclusions:

  • Non-genetic molecular markers hold potential for understanding POAG.
  • Further validation studies are crucial to confirm the role of these markers in POAG.
  • Validated markers could lead to improved diagnostic tools and targeted therapies for POAG.