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Updated: May 20, 2026
09:37
An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
Minireview: nuclear receptor and coregulator proteomics--2012 and beyond
Bert W O'Malley1, Anna Malovannaya, Jun Qin
1Baylor College of Medicine, Department of Cellular Biology, One Baylor Plaza, Houston Texas 77030-3498, USA. berto@bcm.edu
Molecular Endocrinology (Baltimore, Md.)
|June 30, 2012
Summary
The National Institutes of Health
Area of Science:
- Proteomics
- Molecular Biology
- Genetics
Background:
- Nuclear receptors are key regulators of gene expression.
- Coregulator complexes modulate nuclear receptor activity.
- Understanding these interactions is crucial for disease research.
Purpose of the Study:
- To present a summary of the proteomics of nuclear receptor coregulator complexes.
- To highlight the utility of the National Institutes of Health-sponsored Nuclear Receptor Signaling Atlas (NURSA) Proteomics Atlas data.
- To emphasize the application of this data in understanding polygenic diseases.
Main Methods:
- Decade-long proteomic analysis of human cell nuclear receptor coregulator complexes.
- Cataloging the steady-state interactome of these complexes.
- Data compilation and presentation for future exploitation.
Main Results:
- Comprehensive catalog of nuclear receptor coregulator complex composition.
- Demonstration of how NURSA data can be utilized.
- Identification of coregulator proteins involved in polygenic diseases.
Conclusions:
- The NURSA Proteomics Atlas provides valuable insights into nuclear receptor signaling.
- This resource facilitates the study of molecular mechanisms underlying polygenic diseases.
- Future research can leverage this proteomic data for therapeutic target identification.
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