Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pimozide does not impair sweetness discrimination.

P Willner1, M Papp, G Phillips

  • 1Department of Psychology, City of London Polytechnic, UK.

Psychopharmacology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between weight concern, bullying, cigarette use, and vaping among heterosexual and sexual minority female adolescents.

Public health·2026
Same author

Dispositional moral attribution and association avoidance: explaining chronic mpox stigma even after recovery.

Ethics, medicine, and public health·2025
Same author

End-to-end SARS-CoV-2 transmission risks in sport: Current evidence and practical recommendations.

South African journal of sports medicine·2024
Same author

Contact load practices and perceptions in elite English rugby league: an evaluation to inform contact load guidelines.

South African journal of sports medicine·2024
Same author

The Burden Patients with Myasthenia Gravis Experience in Terms of Breathing, Fatigue, Sleep, Mental Health, Discomfort and Usual Activities in Comparison to the General Population.

Advances in therapy·2023
Same author

People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population: Analysis of Two Observational Studies.

Advances in therapy·2023
Same journal

GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.

Psychopharmacology·2026
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
Same journal

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Psychopharmacology·2026
See all related articles

Pimozide did not alter sweetness perception in rats. This study found that while pimozide affected responsiveness to sweet rewards, it did not change the animals' ability to perceive sweetness intensity.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Pharmacology

Background:

  • Pimozide's effects on sucrose solution preference suggest altered sweetness perception.
  • Previous research indicates neuroleptics can impact reward processing.

Purpose of the Study:

  • To investigate if pimozide decreases the perceived intensity of sweet stimuli in rats.
  • To determine if altered sweetness perception explains pimozide's effect on reward responsiveness.

Main Methods:

  • Rats performed a T-maze conditional discrimination task with varying sucrose concentrations.
  • Pimozide administration effects on discrimination accuracy and running speed were assessed.
  • Thresholds for sweetness perception and just-noticeable differences were evaluated.

Related Experiment Videos

Main Results:

  • Pimozide decreased running speed but did not affect discrimination accuracy.
  • Performance accuracy declined at specific sucrose concentration differences.
  • Pimozide did not alter the threshold for sweetness perception or just-noticeable difference discrimination.

Conclusions:

  • Pimozide does not change the perceived intensity of sweetness.
  • Decreased responsiveness to sweet rewards in neuroleptic-treated rats is not due to altered sweetness perception.