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Updated: May 20, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Can heterotrimeric G proteins help to feed the world?
1Plant Genetic Engineering Laboratory, School of Agriculture and Food Sciences, University of Queensland, Brisbane 4072, Australia. j.botella@uq.edu.au
Abstract:
Recently, two important yield quantitative trait loci (QTLs), GS3 and DEP1, have been cloned in rice (Oryza sativa). Although their relationship has not been established in the 'rice literature', a recent report identified them as heterotrimeric G protein γ subunits. This identification has profound consequences for our current understanding of both QTLs and the plant G protein signaling network and this opinion article discusses how manipulation of G protein signaling may lead to yield improvements in rice and other crop species. Finally, a mechanistic model to explain the seemingly conflicting phenotypes produced by different GS3 and DEP1 alleles is proposed.
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