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[Central hemodynamics in subjects with excess body weight]
Insights
Obesity significantly impacts central hemodynamics, especially in those with chronic coronary heart disease (CCHD). Even in healthy individuals, obesity alters hemodynamic parameters, showing a notable link between cardiovascular function and body mass index.
Area of Science:
- Cardiology
- Physiology
- Public Health
Background:
- Obesity is a growing public health concern.
- Cardiovascular diseases (CVDs) are leading causes of mortality worldwide.
- The relationship between obesity and central hemodynamics requires further elucidation.
Purpose of the Study:
- To investigate the impact of obesity on central hemodynamics (CHD) in patients with and without chronic coronary heart disease (CCHD).
- To explore the correlation between hemodynamic parameters and obesity indicators like Quetelet's index.
Main Methods:
- Tetrapolar rheography was used to assess central hemodynamics in 482 patients.
- Patients were categorized based on the presence of angina pectoris and degree of obesity.
- Data analysis compared hemodynamic profiles across different obesity and disease status groups.
Main Results:
- Patients with CCHD and obesity exhibited the most significant hemodynamic changes.
- Obesity was associated with altered hemodynamic parameters even in individuals without diagnosed CVD.
- A significant correlation was observed between central hemodynamic parameters and Quetelet's index.
Conclusions:
- Obesity demonstrably affects central hemodynamics, exacerbating changes in individuals with CCHD.
- Obesity-induced hemodynamic alterations are present even in the absence of overt cardiovascular disease.
- Quetelet's index serves as a relevant indicator for obesity-related hemodynamic shifts.
Abstract:
A total of 482 patients (271 without any signs of cardiovascular diseases and 211 with angina pectoris) grouped in accordance with the degree of obesity were examined for central hemodynamics (CHD) by means of tetrapolar rheography. The most pronounced changes were recorded in patients with chronic coronary heart disease (CCHD) coupled with obesity, less pronounced in patients without obesity (the difference was significant). The same regularity was established in practically healthy persons: in those with obesity, the hemodynamic shifts significantly differed from the shifts seen in patients without obesity and appeared similar to the parameters of patients with CCHD. A noticeable correlation was established between the CHD parameters and Quetelet's index.