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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Published on: May 10, 2022

Innate type 2 cells and asthma.

Emily Hams1, Padraic G Fallon

  • 1Institute of Molecular Medicine, Trinity College Dublin, Ireland.

Current Opinion in Pharmacology
|July 4, 2012
PubMed
Summary
This summary is machine-generated.

This review highlights the role of innate immune cells, particularly nuocytes, and type 2 cytokines like IL-25 and IL-33, in allergic asthma and pulmonary inflammation, independent of the adaptive immune response.

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Related Experiment Videos

Last Updated: May 20, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

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Published on: May 10, 2022

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Area of Science:

  • Immunology
  • Allergy Research
  • Pulmonary Inflammation

Background:

  • Allergic conditions like asthma are characterized by a Th2 immune response, involving elevated IgE, eosinophils, and cytokines IL-4, IL-5, and IL-13.
  • Recent research implicates additional type 2 cytokines, including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), in the development of allergic diseases.

Purpose of the Study:

  • To review the involvement of innate immune cells and specific type 2 cytokines in the pathogenesis of allergic asthma.
  • To focus on the role of nuocytes in pulmonary inflammation associated with allergic conditions.

Main Methods:

  • Literature review of recent advances in immunology and allergy research.
  • Analysis of the role of innate immune cells and type 2 cytokines in asthma models.
  • Focus on the nuocyte population and its cytokine production.

Main Results:

  • Innate immune cells, stimulated by IL-25, IL-33, and TSLP, produce significant amounts of IL-5 and IL-13.
  • This production occurs independently of the adaptive immune response.
  • Nuocytes are identified as key players in this innate type 2 immune response.

Conclusions:

  • Innate immune cells, especially nuocytes, are crucial in the inflammatory processes of allergic asthma.
  • Type 2 cytokines IL-25, IL-33, and TSLP play a significant role in activating these innate cells.
  • Understanding these innate pathways offers new therapeutic targets for allergic lung diseases.