Related Experiment Video

Updated: Feb 16, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
07:18

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

Published on: October 11, 2022

2.6K

The expression and modulation of CEACAM1 and tumor cell transformation

Valentina Fiori1, Mauro Magnani, Maurizio Cianfriglia

  • 1Diatheva srl, Fano (PU), Italy.

Annali Dell'Istituto Superiore Di Sanita
|July 4, 2012
PubMed
Abstract

Insights

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) acts as a tumor suppressor when its expression is restored. However, its de novo expression correlates with advanced cancers and poor prognosis in various tumor types.

Area of Science:

  • Oncology
  • Cell Adhesion Molecules
  • Cancer Biology

Background:

  • Focuses on Carcinoembryonic antigen-related cell adhesion molecules 1 (CEACAM1), a key molecule in cell adhesion.
  • Highlights CEACAM1's complex modulation and dysregulation in malignant transformations.

Purpose of the Study:

  • To review the dual role of CEACAM1 in cancer, as both a potential tumor suppressor and a marker of malignancy.
  • To investigate the correlation between CEACAM1 expression and patient prognosis.

Main Methods:

  • Literature review focusing on CEACAM1.
  • Immunohistochemical analysis of CEACAM1 expression in various tumor tissues.
  • Clinical data correlation with CEACAM1 expression levels.

Main Results:

  • Restoration of CEACAM1 expression can abolish tumor cell oncogenicity in vivo.
  • De novo CEACAM1 expression is observed in advanced stages of melanoma, NSCLC, and other carcinomas.
  • Immunohistochemical and clinical data confirm a correlation between CEACAM1 cell surface expression and poor prognosis.

Conclusions:

  • CEACAM1 exhibits context-dependent roles in cancer progression.
  • CEACAM1 expression on tumor cells is a significant indicator of poor prognosis.
  • Further research into CEACAM1's therapeutic potential is warranted.

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.6K
Floral-dip Transformation of Arabidopsis thaliana to Examine pTSO2::β-glucuronidase Reporter Gene Expression10:24

Floral-dip Transformation of Arabidopsis thaliana to Examine pTSO2::β-glucuronidase Reporter Gene Expression

Published on: June 11, 2010

37.2K

Related Concept Videos

Transformation01:26

Transformation

Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
1.1K
Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.4K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

No description available
5.6K
Transformers01:26

Transformers

A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
2.0K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
25.0K