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Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
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Published on: December 22, 2023

Fetomaternal hemorrhage in the second trimester.

Waltraut M Merz1, Franziska Patzwaldt, Rolf Fimmers

  • 1Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, Sigmund-Freud-Strasse 25, Bonn, Germany. waltraut.merz@ukb.uni-bonn.de

Journal of Perinatal Medicine
|July 4, 2012
PubMed
Summary

Fetomaternal hemorrhage (FMH) is increased in second-trimester pregnancies with fetal anomalies. Invasive procedures did not impact FMH, suggesting abnormal pregnancy causes increased fetal red blood cell transfer.

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Published on: February 15, 2013

Area of Science:

  • Maternal-fetal medicine
  • Fetal diagnostics

Background:

  • Fetomaternal hemorrhage (FMH) is the transfer of fetal blood cells to the maternal circulation.
  • The rate and quantity of FMH in second-trimester pregnancies with fetal anomalies are not well understood.

Purpose of the Study:

  • To investigate the rate and quantity of FMH in second-trimester pregnancies with fetal anomalies.
  • To assess the impact of invasive prenatal procedures and termination on FMH.

Main Methods:

  • Blood samples were collected from women undergoing pregnancy termination.
  • Dual-color flow cytometry was used to analyze fetal red blood cells (HbF cells).
  • Clinical parameters were assessed for association with FMH.

Main Results:

  • 91.0% of specimens showed HbF cells.
  • FMH ≥30 mL occurred in 3.0% of cases, and chronic FMH (≥40% fetoplacental volume) in 7.5%.
  • No clinical parameters or termination procedures were associated with increased FMH.

Conclusions:

  • Second-trimester pregnancies with fetal anomalies exhibit increased fetomaternal red blood cell transfer compared to normal term pregnancies.
  • Invasive procedures do not appear to influence FMH.
  • Abnormalities in the uteroplacental interface during abnormal pregnancies are hypothesized to cause increased FMH.