Related Experiment Videos
Cell mediated immunity in herpes simplex keratitis in man.
J S Saini1, U Datta, D Pradhan
1Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Acta Ophthalmologica
|October 1, 1990
Summary
Herpes simplex keratitis severity correlates with immune response. Lower active T-cells and macrophage inhibition factor (MIF) indicate a weaker cell-mediated immunity, particularly in severe or bilateral cases.
Area of Science:
- Ophthalmology
- Immunology
- Virology
Background:
- Herpes simplex keratitis (HSK) presents with varied clinical manifestations.
- These variations are often linked to the host's immune response against the herpes simplex virus.
Purpose of the Study:
- To investigate the role of lymphocyte subpopulations and macrophage inhibition factor (MIF) in HSK.
- To correlate immune response levels with HSK severity and healing.
Main Methods:
- Assessed active T-lymphocytes, total E-rosette-forming cells (E-RFC), and MIF.
- Compared immune parameters between active and healed HSK, unilateral and bilateral cases, and epithelial versus stromal keratitis.
- Absolute lymphocyte counts and B-lymphocyte levels were also enumerated.
Main Results:
- Significantly lower active T-cells and MIF were observed in active HSK compared to healed stages and controls.
- More pronounced deficiencies in active T-cells and MIF were noted in bilateral and stromal keratitis compared to unilateral and epithelial forms, respectively.
- Immune parameters improved upon healing, returning to levels comparable to normal subjects.
Conclusions:
- HSK severity is associated with a diminished cell-mediated immune response.
- Stromal and bilateral HSK exhibit a more marked deficiency in cell-mediated immunity.
- The level of cell-mediated immune response is directly relatable to HSK manifestations and healing patterns.