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Updated: May 20, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Transplant therapy for type 1 diabetes mellitus.

G E Loss, H P Grewal

Ochsner Journal

|July 4, 2012

Summary

Pancreas transplantation is the sole treatment for insulin-dependent diabetes mellitus that restores normal blood sugar and regulatory control. Advances in immunosuppression and surgical techniques improve transplant success, renewing interest in islet cell transplantation.

Area of Science:

Endocrinology
Transplantation immunology
Metabolic diseases

Background:

Insulin-dependent diabetes mellitus (IDDM) affects over a million US patients.
Exogenous insulin therapy has limitations in achieving optimal glycemic control.
Pancreas transplantation offers a potential cure by restoring euglycemia and regulatory feedback.

Purpose of the Study:

To review the current status and recent advances in pancreas and islet cell transplantation for IDDM.
To highlight improvements in immunosuppressive regimens and surgical techniques.
To discuss the renewed interest in islet cell transplantation due to purification and immunosuppression advancements.

Main Methods:

Review of current literature on pancreas and islet cell transplantation.

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Analysis of advancements in immunosuppressive therapies.

Evaluation of surgical technique improvements and their impact on outcomes.

Main Results:

Pancreas transplantation is the only treatment restoring normal glucose levels and feedback control.
Improved immunosuppression and surgical techniques have enhanced patient and graft survival rates.
Advances in islet cell purification and targeted immunosuppression are increasing the viability of islet cell transplantation.

Conclusions:

Pancreas transplantation remains the gold standard for treating IDDM, offering a cure.
Ongoing research in immunosuppression and surgical procedures continues to improve outcomes.
Islet cell transplantation is a promising alternative, with recent advances making it a viable option.