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Updated: May 20, 2026

10:03
Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
Published on: November 11, 2016
Engineering hematopoietic stem cells to create melanoma specific CTL
1Department of Medicine; Division of Hematology-Oncology; UCLA AIDS Institute; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.
Oncoimmunology
|July 4, 2012
Abstract:
Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow.

