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Updated: May 20, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
Andrea Facciabene1, Stephen Santoro, George Coukos
1Ovarian Cancer Research Center; Perelman School of Medicine; University of Pennsylvania; Philadelphia, USA.
Abstract:
We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.
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