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Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial
S Blake Wachter1, Edward M Gilbert
1Division of Cardiology, University of Utah, Salt Lake City, Utah, USA.
Abstract:
β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker trials β-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of β-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways.
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