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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Published on: November 20, 2015

Idiopathic polyhydramnios and postnatal abnormalities.

Harald Abele1, Sandra Starz, Markus Hoopmann

  • 1Department of Obstetrics and Gynaecology, University of Tübingen, Tübingen, Germany.

Fetal Diagnosis and Therapy
|July 5, 2012
PubMed
Summary
This summary is machine-generated.

Polyhydramnios, excessive amniotic fluid, is unexplained in about 40% of pregnancies. In 10% of these cases, fetal anomalies are only detected after birth, as antenatal characteristics do not differ significantly.

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Area of Science:

  • Perinatology
  • Fetal Medicine
  • Obstetrics

Background:

  • Polyhydramnios, defined as deepest pool of amniotic fluid ≥8 cm, is a condition requiring careful evaluation.
  • Identifying the causes of polyhydramnios is crucial for optimal pregnancy management and fetal outcomes.

Purpose of the Study:

  • To determine the proportion and types of fetal anomalies associated with polyhydramnios.
  • To investigate if antenatal characteristics differ in pregnancies with idiopathic polyhydramnios where anomalies are diagnosed postnatally.

Main Methods:

  • Retrospective study of 272 pregnancies with polyhydramnios.
  • Included detailed ultrasound, glucose tolerance test, and TORCH serology.
  • Analyzed antenatal characteristics for idiopathic polyhydramnios cases.

Main Results:

  • Fetal anomalies occurred in 32.7% and diabetes in 23.9% of cases.
  • Idiopathic polyhydramnios was observed in 43.4% of pregnancies.
  • Postnatal anomalies (mainly gastrointestinal atresia) were found in 9.3% of idiopathic cases, with no significant difference in antenatal markers.

Conclusions:

  • Approximately 40% of polyhydramnios cases remain unexplained antenatally.
  • Fetal anomalies are identified postnatally in about 10% of idiopathic cases.
  • Antenatal indicators like amniotic fluid volume, fetal weight, and maternal/gestational age do not reliably predict these late-diagnosed anomalies.