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Structural determinants of CaV1.3 L-type calcium channel gating.

Andreas Lieb1, Anja Scharinger, Simone Sartori

  • 1Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Austria.

Channels (Austin, Tex.)
|July 5, 2012
PubMed
Summary

The C-terminal modulatory domain (CTM) regulates Ca(v)1.3 channel function. A rat variant (rCa(v)1.3(scg)) lacks a functional CTM, exhibiting distinct gating properties due to specific amino acid differences compared to the functional rat Ca(v)1.3(L) channel.

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