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Pharmacogenetics and pharmacogenomics: role of mutational analysis in anti-cancer targeted therapy

A Savonarola1, R Palmirotta, F Guadagni

  • 1Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro--Piazza Giulio Cesare 11, Bari, Italy. annalisa.savonarola@gmail.com

The Pharmacogenomics Journal
|July 5, 2012
PubMed

Insights

Cancer pharmacogenomics uses genetic variants to personalize cancer treatment and prevention for better efficacy and safety. This review highlights how analyzing mutations can bridge the gap between genetic knowledge and clinical practice.

Area of Science:

  • Oncology
  • Pharmacogenomics
  • Genetics

Background:

  • Personalized cancer treatment relies on understanding individual genetic variations.
  • Genetic variants in drug-metabolizing enzymes, transporters, and targets influence treatment response.
  • A gap exists between current pharmacogenomic knowledge and its clinical application.

Purpose of the Study:

  • To review the significance of mutational analyses in predicting individual responses to cancer therapy.
  • To enhance the translation of genetic information into clinical practice for improved cancer care.

Main Methods:

  • Review of recent advances in genomic research related to cancer pharmacogenomics.
  • Focus on mutational analyses for predicting treatment response.
  • Analysis of the translational impact of genetic information.

Main Results:

  • Genetic variants critically impact therapeutic efficacy and safety.
  • Targeted cancer agents are increasingly designed based on molecular alterations.
  • Despite advances, clinical application of pharmacogenomic knowledge remains limited.

Conclusions:

  • Mutational analyses are relevant for predicting individual antitumor therapy response.
  • Improving the translational impact of genetic information is crucial for clinical practice.
  • Pharmacogenomics holds promise for personalized cancer treatment and prevention.

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