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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: May 20, 2026

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Modeling human cortical development in vitro using induced pluripotent stem cells.

Jessica Mariani¹, Maria Vittoria Simonini, Dean Palejev

¹Program in Neurodevelopment and Regeneration, Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.

Proceedings of the National Academy of Sciences of the United States of America

|July 5, 2012

Summary

This summary is machine-generated.

Human induced pluripotent stem cells (hiPSCs) can model early human brain development. These cells form 3D structures that mimic the embryonic telencephalon, aiding research into brain disorders.

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Area of Science:

Neuroscience
Developmental Biology
Stem Cell Biology

Background:

Human induced pluripotent stem cells (hiPSCs) offer a unique model for studying human development.
Understanding early human brain development is crucial for addressing neurological disorders.

Purpose of the Study:

To investigate the potential of hiPSCs to model human telencephalic development in vitro.
To characterize the cellular and molecular organization of hiPSC-derived brain structures.

Main Methods:

Culturing hiPSCs in suspension with neuralizing factors to promote self-organization.
Analyzing gene expression profiles and cellular composition of 3D structures.

Main Results:

hiPSCs generated 3D structures with polarized radial glia, progenitors, and layer-specific cortical neurons.
These structures exhibited gene expression patterns characteristic of the embryonic telencephalon.
Transcriptome analysis showed high correlation with early human cortical development (8-10 weeks post-conception).

Conclusions:

hiPSCs can recapitulate key aspects of human telencephalic (pallial) development.
This hiPSC model provides a valuable platform for studying human brain development and cortical disorders.