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Updated: May 20, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds
Ute Philipp1, Andrea Vollmar, Jens Häggström
1Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany. ute.philipp@tiho-hannover.de
Abstract:
Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.
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Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
