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Bacterial translocation in colorectal cancers.
D Lescut1, J F Colombel, P Vincent
1Clinique des Maladies de l'Appareil Digestif, CHU Lille, France.
Gastroenterologie Clinique Et Biologique
|January 1, 1990
Summary
Bacterial translocation, the movement of gut bacteria to other organs, is more common in colorectal cancer patients. This highlights the importance of antibiotics before colorectal cancer surgery.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Microbiology
Background:
- Bacterial translocation (BT) from the gastrointestinal tract to internal organs is not well understood in humans.
- Investigating BT is crucial for understanding surgical risks and patient outcomes.
Purpose of the Study:
- To compare the incidence of bacterial translocation in patients undergoing colorectal cancer surgery versus other abdominal surgeries.
- To identify potential sources and locations of bacterial translocation in colorectal cancer patients.
Main Methods:
- Surgical specimens (pericolonic lymph nodes, liver, portal blood, peritoneum) were collected from 20 colorectal cancer patients and 20 controls before antibiotic administration.
- Bacterial presence in any specimen defined bacterial translocation.
Main Results:
- Bacterial translocation occurred in 65% of colorectal cancer patients, compared to 30% in the control group (p<0.05).
- The increased incidence in colorectal cancer was primarily linked to bacteria in pericolonic lymph nodes near the tumor.
- Intestinal bacteria were found to translocate from the bowel lumen in a significant number of colorectal cancer patients.
Conclusions:
- Colorectal cancer patients exhibit a higher incidence of bacterial translocation.
- Translocation is often associated with pericolonic lymph nodes adjacent to colorectal tumors.
- Prophylactic antibiotics are essential in colorectal cancer surgery due to the high risk of bacterial translocation.