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Updated: May 20, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Cheese: an old drug in a new wrapper
Jane Carlisle Maxwell1, John J Coleman, Sing-Yi Feng
1University of Texas, School of Social Work, Austin 78712-0358, USA. jcmaxwell@mail.utexas.edu
An outbreak of "cheese" heroin affected Hispanic youth in Dallas, primarily inhalers. Early intervention was successful, but treatment retention and cultural barriers remain challenges for this vulnerable population.
Area of Science:
- Public Health
- Substance Abuse Research
- Adolescent Health
Background:
- An outbreak of "cheese" heroin, a substance containing diphenhydramine and acetaminophen, emerged in Dallas around 2004.
- The outbreak primarily affected Hispanic immigrant youth, who were initially inhaler users at risk of transitioning to injection drug use.
Purpose of the Study:
- To investigate the "cheese" heroin outbreak among youth in Dallas.
- To understand the social factors, strengths, and deficits of the affected youth population.
- To monitor the outbreak's progression and inform response strategies.
Main Methods:
- Utilized multiple data sources: surveys, emergency department data, law enforcement records, treatment program data, coroner reports, and interviews.
- Collected data from users and key informants to gain comprehensive insights.
Main Results:
- Overdose deaths peaked in 2006, followed by peak survey responses in 2007 and treatment admissions in 2008 among heroin users under 20.
- Hispanic youth in treatment reported fewer problems and were more family-supported than Anglo counterparts.
- Treatment completion rates were low (53%), with 60% of Hispanic youth having prior treatment; cocaine and/or benzodiazepines were involved in 32% of adolescent heroin deaths.
Conclusions:
- Multiple data sources facilitated rapid identification and monitoring of the "cheese" heroin outbreak.
- Treatment retention and readmission were significant issues, with cultural factors like immigration status and language posing barriers.
- Emphasized the critical role of completing treatment as an inhaler to prevent transitioning to injection drug use.
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