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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Visual outcomes after carotid reconstructive surgery for ocular ischemia
V V Neroev1, T N Kiseleva, S K Vlasov
1Ultrasound Diagnostics, The Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia.
Eye (London, England)
|July 7, 2012
Summary
Carotid artery surgery significantly improved vision and ocular blood flow in patients with ocular ischemic syndrome (OIS). This surgical intervention demonstrated positive long-term effects on visual acuity and blood circulation in the eyes.
Area of Science:
- Ophthalmology
- Vascular Surgery
- Neuroscience
Background:
- Ocular ischemic syndrome (OIS) is a severe condition affecting vision due to impaired blood flow.
- Carotid artery disease is a common cause of reduced blood flow to the brain and eyes.
- Evaluating the impact of surgical intervention on ocular health is crucial for patient outcomes.
Purpose of the Study:
- To assess the long-term effects of carotid artery surgery on ocular functions.
- To determine the influence of this surgery on ocular blood flow in patients with OIS.
- To compare outcomes in acute versus chronic forms of OIS.
Main Methods:
- A cohort of 180 patients with OIS (104 acute, 76 chronic) underwent carotid artery surgery.
- Ocular functions including visual acuity and electrophysiological tests (TES, LON) were evaluated.
- Ocular blood flow in orbital vessels was assessed pre-surgery and at 6 and 12 months post-surgery.
Main Results:
- Visual acuity improved significantly in patients with acute OIS (P<0.05).
- Electrophysiological measures (TES, LON) showed significant improvement (P<0.01).
- Blood flow velocities in key orbital arteries increased, with reduced vasoresistance at 6 and 12 months post-surgery (P<0.05).
Conclusions:
- Carotid artery surgery is an effective treatment for improving ocular blood flow in OIS patients.
- The surgery yields positive long-term benefits for both acute and chronic ocular ischemia.
- Enhanced ocular blood flow contributes to improved visual function after surgery.