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Updated: May 20, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Central line-associated bloodstream infection prevention
Sarah E Miller1, Lisa L Maragakis
1Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. smill106@jhmi.edu
Implementing evidence-based practices for central line insertion and maintenance significantly reduces central line-associated bloodstream infections (CLABSI). Continued research is needed for non-ICU settings.
Area of Science:
- Infection Control
- Healthcare Epidemiology
- Patient Safety
Background:
- Central line-associated bloodstream infections (CLABSI) remain a significant healthcare-associated complication.
- Recent trends show a dramatic decrease in CLABSI rates in US intensive care units (ICUs).
Purpose of the Study:
- To review and summarize recent literature on strategies for preventing CLABSI.
- To highlight advancements in CLABSI prevention, including insertion and maintenance practices.
Main Methods:
- Literature review of recent studies on CLABSI prevention.
- Analysis of data from the National Healthcare Safety Network (NHSN).
Main Results:
- Multifaceted approaches focusing on evidence-based central line insertion and maintenance practices have led to reduced CLABSI rates.
- Daily chlorhexidine gluconate (CHG) bathing shows benefit in the ICU population.
- CLABSI prevention efforts are expanding to pediatric and non-ICU settings.
Conclusions:
- A comprehensive strategy for central line care improves prevention in both ICU and non-ICU environments.
- Further research is required to establish specific benchmarks and prevention guidelines for non-ICU settings.
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