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Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 20, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Mesenchymal stem cells for cartilage engineering.

C Huselstein¹, Y Li, X He

¹CNRS, UMR 7561 et FR CNRS-INSERM-UHP-CHU 3209, Faculté de Médecine, Vandoeuvre-les-Nancy, France. Celine.Huselstein@medecine.uhp-nancy.fr

Bio-Medical Materials and Engineering

|July 7, 2012

Summary

This summary is machine-generated.

Articular cartilage repair remains challenging. Mesenchymal stem cells (MSCs) show promise for tissue engineering and regenerative medicine, offering an alternative to autologous chondrocyte transplantation (ACT) for cartilage defects.

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Last Updated: May 20, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Area of Science:

Orthopaedic surgery
Musculoskeletal medicine
Regenerative medicine

Background:

Articular cartilage injuries are difficult to treat due to poor natural repair.
Current treatments like autologous chondrocyte transplantation (ACT) yield inconsistent outcomes.
Large cartilage defects necessitate advanced treatment strategies.

Purpose of the Study:

To explore tissue engineering parameters for articular cartilage repair.
To evaluate mesenchymal stem cells (MSCs) as an alternative cell source.
To compare MSCs and autologous chondrocytes for cartilage engineering.

Main Methods:

Review of tissue engineering principles.
Analysis of mesenchymal stem cells (MSCs) potential.
Comparison of cell sources for articular cartilage repair.

Main Results:

Mesenchymal stem cells (MSCs) present a viable option for cartilage tissue engineering.
Autologous chondrocytes (ACs) have limitations in current applications.
Tissue engineering offers a promising avenue for large chondral defects.

Conclusions:

Mesenchymal stem cells (MSCs) offer significant potential in regenerative medicine for cartilage repair.
Optimizing tissue engineering strategies is crucial for effective cartilage regeneration.
Further research is needed to fully leverage MSCs and tissue engineering for articular cartilage defects.