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Updated: May 20, 2026
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Percutaneous balloon valvuloplasty inpatients with pulmonary valve stenosis: a single center experiment
Alireza Ahmadi1, Mohammadreza Sabri
1Department of Pediatrics, Pediatric Cardiology,Faculty of Medicine, and Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. ahmadi_cardio@yahoo.com
Insights
Balloon pulmonary valvuloplasty (BPV) effectively treats pulmonary valve stenosis (PVS) in children and adults. This procedure significantly reduces pressure gradients across the pulmonary valve with a low complication rate.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Interventional Cardiology
Background:
- Pulmonary valve stenosis (PVS) is a critical acyanotic congenital heart defect in children.
- Balloon pulmonary valvuloplasty (BPV) is the preferred treatment for moderate to severe PVS across all age groups.
- This study assesses the short-term outcomes of BPV in patients with PVS at the Isfahan Heart Center.
Purpose of the Study:
- To evaluate the effectiveness and safety of balloon pulmonary valvuloplasty (BPV) for treating pulmonary valve stenosis (PVS).
- To report on the short-term clinical outcomes of BPV in a regional patient cohort.
Main Methods:
- Thirty-seven patients (0.6-16 years) with moderate to severe PVS underwent cardiac catheterization.
- Balloon pulmonary valvuloplasty (BPV) was performed on 34 patients.
- Right ventricle and pulmonary artery pressures and gradients were measured pre- and post-BPV.
Main Results:
- BPV achieved successful pulmonary valve dilation in 85% (32/34) of cases.
- Significant reductions in right ventricle-pulmonary artery systolic pressure gradient were observed (p < 0.001).
- No major complications occurred; two patients with subvalvar PVS required surgical intervention.
Conclusions:
- BPV is an effective and safe treatment for moderate to severe pulmonary valve stenosis (PVS).
- The procedure successfully reduces the RV-PA systolic pressure gradient.
- BPV offers a low complication rate for PVS management.
Background:
Pulmonary valve stenosis (PVS) is one of the most important acyanotic congenital heart diseases in children. Over the last years, balloon pulmonary valvuloplasty (BPV) has become the treatment of choice for the relief of moderate to severe valvular pulmonic stenosis in all age groups. The aim of current study was to report our regional survey on the short term outcomes of BPV among patients with PVS treated in Isfahan Hearth center.
Methods:
Thirtyseven patients with moderate and severe PS based on echocardiography, aged between 0.6 and 16 years, underwent catheterization and angiography. Balloon pulmonary valvuloplasty was performed for thirty four patients. Right ventricle and pulmonary artery pressure and pressure gradient was measured before and after valvuloplasty.
Results:
The pulmonary valvuloplasty was successful in 32 (85%) of 34 attempts. Immediately after dilation, right ventricle and pulmonary artery pressure and pressure gradient decreased from 73.0 +/- 48.0 to 38.4 +/- 23.1 mmHg, from 35.2 +/- 22.1 to 20.7 +/- 9.7 mmHg and from 79.0 +/- 32.1 to 33.4 +/- 19.9 mmHg, respectively (p < 0.001).There was no major complication. Two patients with significant subvalvar PS referred to surgeon for infundibular resection.
Conclusion:
BPV was an effective procedure to treat PVS in patients with moderate to severe stenosis. It effectively reduced right ventricle-pulmonary artery systolic pressure gradient with low complication.
