Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short- and Long-Term Efficacy and Safety of Levosimendan in VA-ECMO Weaning: The WEANILEVO Randomized Double-Blind Multicenter Trial.

Anesthesiology·2026
Same author

Irritant occupational exposure and specific-IgE sensitisation in the EGEA cohort.

Occupational and environmental medicine·2026
Same author

HSK21542 for Postoperative Analgesia in Gynecological Surgery: A Pooled Post-Hoc Analysis of Two Phase III Randomized Controlled Trials.

Anesthesia and analgesia·2026
Same author

Occupational Asthma Without Nonspecific Bronchial Hyperresponsiveness.

The journal of allergy and clinical immunology. In practice·2026
Same author

Heart-Lung transplantation: Meeting allocation challenges in France.

JHLT open·2026
Same author

Occupational Asthma Due to Hair Dyes Containing Para-Amino Compounds.

American journal of industrial medicine·2025
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

[Allergic risk in anaesthesia].

Paul Michel Mertes1, Frédéric De Blay, Siwei Dong

  • 1CHU de Nancy, hôpital Central, service d'anesthésie-réanimation chirurgicale, 54035 Nancy cedex, France. pm.mertes@chu-nancy.fr

Presse Medicale (Paris, France : 1983)
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Anaphylactic reactions during anesthesia, often IgE-mediated, are common, particularly in adult females. Neuromuscular blocking agents are the most frequent culprits, necessitating prompt diagnosis and treatment with epinephrine.

More Related Videos

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
04:56

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
04:56

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

Area of Science:

  • Anesthesiology and Immunology
  • Clinical Pharmacology
  • Allergy and Clinical Immunology

Context:

  • Anaphylactic reactions during anesthesia represent a significant clinical challenge with variable incidence globally.
  • In France, allergic reactions occur at an estimated rate of 100.6 per million procedures, with a notable female predominance in adults.
  • Neuromuscular blocking agents (NMBAs) are the leading cause of intraoperative anaphylaxis in adults, followed by latex and antibiotics.

Purpose:

  • To summarize the incidence, causes, clinical presentation, and diagnostic approaches for anaphylactic reactions during anesthesia.
  • To highlight the importance of identifying specific allergens, such as NMBAs and latex, in the context of anesthesia.
  • To outline current management strategies, including immediate interventions and long-term prevention.

Summary:

  • Anaphylaxis during anesthesia can be immune (IgE- or IgG-mediated) or non-immune. Incidence varies, with NMBAs being the most common trigger in adults.
  • Clinical symptoms range from pulselessness and erythema to cardiovascular arrest. Diagnosis involves mediator measurement (tryptase, histamine) and specific IgE detection.
  • Management includes allergen avoidance, epinephrine titration, and volume expansion. Latex-free environments and targeted allergy testing are key preventive measures.

Impact:

  • Improved understanding of anaphylaxis triggers and patterns during anesthesia can lead to enhanced patient safety protocols.
  • Early recognition and appropriate management of anaphylactic reactions can reduce morbidity and mortality.
  • This information supports the development of targeted allergy investigations and preventive strategies for at-risk patient populations.