Electrochemical behavior of indolone-N-oxides: relationship to structure and antiplasmodial activity
Karine Reybier1, Thi Hoang Yen Nguyen, Hany Ibrahim
1Université de Toulouse, UPS, PHARMA-DEV, UMR 152, 118 route de Narbonne, F-31062 Toulouse cedex 9, France. karine.reybier-vuattoux@univ-tlse3.fr
Abstract:
Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodium falciparum, the parasite responsible for malaria. The bioreductive character of these molecules was investigated using cyclic voltammetry and EPR spectroelectrochemistry to examine the relationship between electrochemical behavior and antimalarial activity and to understand their mechanisms of action. For all the compounds (37 compounds) studied, the voltammograms recorded in acetonitrile showed a well-defined and reversible redox couple followed by a second complicated electron transfer. The first reduction (-0.88V
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