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Updated: May 20, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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C/EBPα bypasses cell cycle-dependency during immune cell transdifferentiation.

Alessandro Di Tullio1, Thomas Graf

  • 1Gene Regulation, Stem Cells and Cancer Program, Center for Genomic Regulation and Pompeu Fabra University, Barcelona, Spain.

Cell Cycle (Georgetown, Tex.)
|July 10, 2012
PubMed
Summary

Cell division is not essential for converting pre-B cells into macrophages using transcription factors C/EBPα or C/EBPβ. High C/EBPα levels accelerate differentiation and cell cycle arrest, differing from induced pluripotent stem cell reprogramming.

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