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Persistent neutrophilic meningitis

J E Peacock1

  • 1Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.

Infectious Disease Clinics of North America
|December 1, 1990
PubMed

Insights

Persistent neutrophilic meningitis is a distinct chronic meningitis variant. Early recognition is vital for appropriate empiric therapy, differing from classic meningitis treatments.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Chronic meningitis can present with diverse cerebrospinal fluid (CSF) profiles.
  • Persistent neutrophilic meningitis is an uncommon but recognized subtype.

Purpose of the Study:

  • To define the characteristics of persistent neutrophilic meningitis.
  • To highlight the importance of recognizing this syndrome for appropriate management.

Main Methods:

  • Analysis of serial CSF studies in patients with chronic meningitis.
  • Identification of key diagnostic criteria: sustained CSF neutrophilia and hypoglycorrhachia (>1 week).

Main Results:

  • Persistent neutrophilic meningitis is characterized by persistent CSF neutrophilia and hypoglycorrhachia.
  • Identified etiologies include bacteria (e.g., Brucella, Nocardia, Actinomyces) and fungi (e.g., Candida, Aspergillus).

Conclusions:

  • Persistent neutrophilic meningitis is a distinct clinical entity.
  • Empiric therapy for this condition may differ from that for classic chronic meningitis, necessitating prompt diagnosis.

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