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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Updated: May 20, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
09:47

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Mesenchymal stem cell therapy and lung diseases.

Khondoker M Akram1, Sohel Samad, Monica Spiteri

  • 1Guy Hilton Research Centre, Institute of Science and Technology in Medicine, Keele University, Stoke-on-Trent, ST4 7QB, UK.

Advances in Biochemical Engineering/Biotechnology
|July 10, 2012
PubMed
Summary

Mesenchymal stem cells (MSCs) can repair lung injury by reducing inflammation and promoting cell survival. Understanding MSC mechanisms is key to optimizing their use in regenerative medicine for conditions like acute alveolar injury.

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Published on: December 12, 2025

Area of Science:

  • Regenerative Medicine
  • Cell Therapy
  • Pulmonary Medicine

Background:

  • Mesenchymal stem cells (MSCs) are adult stem cells with multipotent differentiation potential.
  • MSCs secrete paracrine factors with anti-inflammatory, anti-apoptotic, and immunomodulatory effects.
  • Clinical trials confirm the safety and efficacy of MSCs in human applications.

Purpose of the Study:

  • To elucidate the mechanisms of Mesenchymal stem cell-mediated acute alveolar injury repair.
  • To understand how MSCs interact with the inflammatory environment in injured lung tissue.
  • To identify key molecular pathways involved in MSC-driven lung regeneration.

Main Methods:

  • Review of proposed mechanisms for MSC delivery (intratracheal, intravenous) into injured alveoli.
  • Analysis of MSC interactions with immune cells (T-lymphocytes, macrophages) and inflammatory mediators (IL-1β, TNF-α).
  • Examination of MSC-induced changes in alveolar epithelial cells (AEC) apoptosis and proliferation (Bcl-2, KGF).

Main Results:

  • MSCs may reduce alveolar inflammation by inhibiting T-lymphocyte proliferation and TNF-α secretion.
  • MSC-derived IL-1 receptor antagonist (IL-1RN) and prostaglandin-E2 (PGE2) modulate macrophage activity and IL-10 secretion.
  • MSCs can inhibit AEC apoptosis via Bcl-2 up-regulation and promote epithelial repair through KGF-stimulated AECII proliferation.

Conclusions:

  • Mesenchymal stem cells offer a promising therapeutic strategy for acute alveolar injury.
  • MSC-mediated repair involves complex anti-inflammatory and pro-regenerative signaling pathways.
  • Further research into MSC mechanisms is crucial for optimizing clinical application in lung diseases.