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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Updated: May 20, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Obesity and the elderly.

Elisabeth M H Mathus-Vliegen1

  • 1Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam, Amsterdam. e.mathus-vliegen@amc.uva.nl

Journal of Clinical Gastroenterology
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Obesity is increasing in older adults. Treatment is recommended for obese elderly individuals with complications, focusing on lifestyle changes to prevent muscle and bone loss.

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Area of Science:

  • Gerontology
  • Public Health
  • Obesity Research

Background:

  • Rising global obesity rates disproportionately affect aging populations.
  • Significant projections indicate a substantial increase in the elderly demographic in the US and Europe.
  • Obesity among individuals aged 60+ is a growing concern, with millions affected in the US and EU.

Purpose of the Study:

  • To review the current understanding of obesity in the elderly.
  • To outline appropriate treatment strategies for obesity in older adults.
  • To highlight the importance of preserving muscle and bone mass during weight loss interventions.

Main Methods:

  • Analysis of meta-analyses on obesity and related health risks in the elderly.
  • Review of lifestyle intervention components including diet, protein intake, and exercise.
  • Examination of adherence rates and factors influencing physical activity in older adults.

Main Results:

  • Mortality and morbidity risks increase significantly with a body mass index (BMI) over 30 kg/m².
  • Lifestyle interventions, including a balanced diet and multicomponent exercise, show adherence rates around 75%.
  • Pharmacotherapy and bariatric surgery roles in the elderly remain largely unstudied due to exclusion criteria in most trials.

Conclusions:

  • Obesity treatment in the elderly should target individuals with BMI >30 kg/m² and associated health issues.
  • Lifestyle interventions are the primary approach, emphasizing muscle and bone health to prevent sarcopenic obesity.
  • Further research is needed to establish the safety and efficacy of pharmacotherapy and bariatric surgery in older adults.