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Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory
Rachael M Crist1, Jennifer Hall Grossman, Anil K Patri
1Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Summary
The Nanotechnology Characterization Laboratory (NCL) analyzed over 250 nanoparticle platforms for cancer therapy and imaging. This review highlights common nanoformulation errors in synthesis, purification, and characterization to improve future research.
Area of Science:
- Nanomedicine
- Materials Science
- Biotechnology
Background:
- The Nanotechnology Characterization Laboratory (NCL) has extensive experience characterizing diverse nanomaterials.
- Over 250 nanoparticle platforms for cancer therapeutics and imaging have been analyzed over six years.
- Investigator backgrounds include government, academia, and industry.
Purpose of the Study:
- To identify and share common pitfalls in nanoparticle formulation and characterization.
- To provide insights into trends in nanoparticle safety and biocompatibility.
- To guide researchers in improving nanoformulation strategies.
Main Methods:
- Characterization of over 250 unique nanomaterials submitted by external investigators.
- Analysis of nanoparticle platforms intended for drug delivery and medical imaging.
- Observation of synthesis, purification, characterization, and analysis processes.
Main Results:
- Identification of recurring mistakes in nanoformulation across various research settings.
- Observation of trends related to nanoparticle safety and biocompatibility.
- Compilation of common oversights in the nanoparticle lifecycle.
Conclusions:
- Sharing NCL's observed common pitfalls can help researchers avoid frequent errors.
- Improved nanoformulation practices are crucial for advancing nanoparticle-based therapeutics and diagnostics.
- This analysis provides valuable guidance for the nanomedicine community.
