Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility of a Center of Mass Based Fuzzy-Logic Phase Detection Algorithm for Post-Spinal Cord Injury Gait.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Exploration of the center of mass kinematics correlation with established gait measures in post-spinal cord injury.

Frontiers in rehabilitation sciences·2026
Same author

Exploring the Integration of Immersive Virtual Reality With Adapted Neuromuscular Stimulation Rowing for Individuals With Spinal Cord Injury.

American journal of physical medicine & rehabilitation·2026
Same author

Feasibility of optimizing muscle activation of individuals with spinal cord injuries to reduce caregiver effort in assisted transfers.

Journal of neuroengineering and rehabilitation·2026
Same author

Maintaining Seated Posture With Feedback Control of Trunk Musculature Via the Networked Neuroprosthesis After Paralysis: A Case Report.

American journal of physical medicine & rehabilitation·2026
Same author

Spinal Reflex Modulation by a Sensory Neuroprosthesis During Gait in an Individual With Lower Limb Loss: Case Report.

American journal of physical medicine & rehabilitation·2026

Related Experiment Video

Updated: May 20, 2026

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

Human distal sciatic nerve fascicular anatomy: implications for ankle control using nerve-cuff electrodes.

Kenneth J Gustafson1, Yanina Grinberg, Sheeba Joseph

  • 1Case Western Reserve University Department of Biomedical Engineering, Neural Engineering Center, Wickenden Building, Rm 108, Cleveland, OH 44106-4912, USA. kjg@case.edu

Journal of Rehabilitation Research and Development
|July 10, 2012
PubMed
Summary

Detailed sciatic nerve anatomy is crucial for designing neural prostheses. This study maps fascicles to enable selective nerve stimulation for improved lower-limb prosthetic control.

More Related Videos

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Related Experiment Videos

Last Updated: May 20, 2026

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Anatomy

Background:

  • Restoring ambulation with neural prostheses requires precise understanding of lower limb nerve anatomy.
  • Current prostheses for balance, foot drop, and propulsion need improved control mechanisms.

Purpose of the Study:

  • To characterize the branching patterns and fascicular organization of the distal sciatic nerve.
  • To provide neuroanatomical data for designing selective nerve-cuff electrodes for ankle movement control.

Main Methods:

  • Dissection of three complete sciatic nerves and their branches from the piriformis to muscle entry points.
  • Creation of fascicle maps from serial sections of the distal nerve segments below the knee.
  • Analysis of branching patterns and fascicle organization in the tibial and common fibular nerves.

Main Results:

  • Consistent branching patterns and fascicle maps were observed across specimens.
  • Fascicles for plantar flexors, dorsiflexors, invertors, and evertors were distinctly separate and functionally organized.
  • Individual muscle fascicles were not discernible at the studied nerve levels.

Conclusions:

  • The distal sciatic nerve exhibits a fascicular organization suitable for selective stimulation.
  • This neuroanatomical knowledge facilitates the design of multicontact nerve-cuff electrodes for precise ankle movement control.
  • The findings support the development of advanced lower-limb neural prostheses.