Related Experiment Video
Updated: May 20, 2026
08:33
Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
Published on: March 24, 2019
14-3-3 proteins in neurological disorders
1Department of Biomedical Sciences, Florida State University College of Medicine Tallahassee, FL 32306, USA.
Summary
14-3-3 proteins, crucial for brain function, are involved in neurological disorders. This review explores their roles in neurodegenerative and neuropsychiatric diseases, highlighting key research findings.
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Background:
- 14-3-3 proteins are a conserved family of ubiquitous regulatory molecules.
- They are highly expressed in the brain and regulate diverse cellular processes.
- These proteins interact with numerous binding partners, influencing neuronal function.
Purpose of the Study:
- To review the established and emerging roles of 14-3-3 proteins in neurological disorders.
- To consolidate current understanding of 14-3-3 protein involvement in neurodegenerative and neuropsychiatric diseases.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of research investigating 14-3-3 protein interactions and functions in the context of disease.
Main Results:
- 14-3-3 proteins significantly impact neural signaling, neuronal development, and neuroprotection.
- Evidence links 14-3-3 protein dysregulation to various neurological conditions.
- Specific roles in diseases like Alzheimer's, Parkinson's, and depression are being elucidated.
Conclusions:
- 14-3-3 proteins are critical regulators of brain function with significant implications for neurological health.
- Further research into 14-3-3 proteins offers potential therapeutic avenues for neurodegenerative and neuropsychiatric diseases.
More Related Videos
Related Concept Videos
01:28Disorders of the Nervous Tissue
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
01:37Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
01:31Neurotransmitters
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...