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Repopulation of ganciclovir-resistant cytomegalovirus by wild-type virus
W Lawrence Drew1, Catherine Liu
1Department of Laboratory Medicine and Medicine, University of California, San Francisco, San Francisco, CA 94143-0654, USA.
Abstract:
We report a patient in whom ganciclovir (GCV)-resistant cytomegalovirus (CMV) was replaced by wild-type virus after discontinuation of GCV/valganciclovir and review other similar cases. Repopulation by wild-type virus may occur soon after discontinuation and may be fostered by discontinuing GCV altogether rather than continuing it in combination with foscarnet when treating patients with GCV-resistant CMV disease.
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