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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: May 20, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Human pluripotent stem cells for modeling toxicity.

R L C Sison-Young1, R Kia, J Heslop

  • 1MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

Advances in Pharmacology (San Diego, Calif.)
|July 11, 2012
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cells offer a promising alternative for predicting xenobiotic toxicity. These advanced models improve upon traditional methods, potentially reducing drug development costs and enhancing patient safety.

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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

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Last Updated: May 20, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
05:49

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Area of Science:

  • Biotechnology
  • Toxicology
  • Stem Cell Research

Background:

  • The increasing development of xenobiotics for various uses necessitates robust toxicity screening.
  • Current animal and in vitro models for xenobiotic safety assessment are costly, animal-intensive, and often lack clinical translatability.
  • High rates of xenobiotic-induced toxicity contribute to patient morbidity and mortality, highlighting limitations in existing safety screening methods.

Purpose of the Study:

  • To review the advancements in using human pluripotent stem cells (hPSCs) for modeling xenobiotic metabolism and toxicity.
  • To discuss the challenges associated with hPSC-based toxicity studies.
  • To provide perspectives on the future applications of hPSCs in drug toxicology and safety pharmacology.

Main Methods:

  • Review of current literature on xenobiotic toxicity screening models.
  • Exploration of human pluripotent stem cell technologies for generating metabolically competent cells.
  • Analysis of hPSC-derived cell types for in vitro disease modeling in toxicology.

Main Results:

  • Human pluripotent stem cells provide a renewable source of metabolically competent cells for toxicity testing.
  • hPSC-derived models offer potential for more accurate prediction of drug toxicity compared to traditional methods.
  • These models can be utilized for in vitro disease modeling relevant to drug toxicology.

Conclusions:

  • Human pluripotent stem cells represent a significant advancement in developing more predictive models for xenobiotic metabolism and toxicity.
  • Overcoming current challenges will be crucial for the widespread adoption of hPSC-based toxicity screening.
  • Future research directions include refining hPSC differentiation protocols and validating their predictive capacity in drug safety assessment.