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Updated: May 20, 2026
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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Longitudinal structure-function relationships with scanning laser ophthalmoscopy and standard achromatic perimetry
Nariman Nassiri1, Naveed Nilforushan, Anne L Coleman
1Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 11, 2012
Summary
Glaucoma progression shows fair structure-function correlation. Structural rim area (RA) decline is not faster in eyes with visual field (VF) progression, highlighting the need for monitoring both structural and functional changes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Neuroscience
Background:
- Glaucoma is a progressive optic neuropathy characterized by structural damage and functional vision loss.
- Early detection and monitoring of glaucoma progression are crucial for timely intervention and preserving vision.
Purpose of the Study:
- To investigate the longitudinal correlations between structural and functional rates of glaucoma progression.
- To assess the relationship between changes in rim area (RA) and visual field (VF) sensitivity over time.
Main Methods:
- Retrospective longitudinal study of 108 eyes with glaucoma.
- Confocal scanning laser ophthalmoscopy (CSLO) for structural assessment (RA) and standard achromatic perimetry (SAP) for functional assessment (VF).
- Linear regression and bivariate correlation analyses to calculate and compare progression rates; linear mixed models to identify predictors.
Main Results:
- The superonasal and superotemporal rim areas showed the highest rates of structural decay.
- Significant correlations were found between specific rim area regions and inferior visual field clusters.
- Progression based on visual field criteria was not associated with significantly higher rates of rim area progression.
Conclusions:
- Longitudinal structure-function relationships in glaucoma are only fair.
- Structural rim area progression rates do not significantly differ between eyes with and without visual field progression.
- Monitoring both structural (e.g., rim area) and functional (visual field) outcomes is essential for accurate glaucoma progression detection.
