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Updated: May 20, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Screening rhodium metallopeptide libraries "on bead": asymmetric cyclopropanation and a solution to the enantiomer
Ramya Sambasivan1, Zachary T Ball
1Department of Chemistry MS 60, Rice University, 6100 Main street, Houston, TX 77005, USA.
Abstract:
Searching with a beady eye: A high-throughput, on-bead screen of rhodium metallopeptide catalysts was developed in a 96-well format for asymmetric cyclopropanation. Different sequences of natural L-amino acids have been identified that produce opposite product enantiomers. In addition to styrene derivatives, high enantioselectivity is observed for vinyl ether and vinyl amine derivatives.
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