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Updated: May 20, 2026

Neurodevelopmental Reflex Testing in Neonatal Rat Pups
Published on: April 24, 2017
The grasp reflex and moro reflex in infants: hierarchy of primitive reflex responses
Yasuyuki Futagi1, Yasuhisa Toribe, Yasuhiro Suzuki
1Department of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan.
Insights
Primitive reflexes like the plantar and palmar grasp reflexes are clinically significant for detecting spasticity and other conditions in infants. The Moro reflex
Area of Science:
- Neuroscience
- Developmental Biology
- Clinical Neurology
Background:
- Primitive reflexes, including grasp and Moro reflexes, are crucial in neonatal assessment.
- These reflexes provide insights into neurological development and potential abnormalities.
- Their underlying spinal reflex mechanisms and higher regulatory control are areas of ongoing research.
Purpose of the Study:
- To highlight the clinical and diagnostic significance of plantar and palmar grasp reflexes.
- To discuss the role of the Moro reflex in neonatal assessment and its diagnostic implications.
- To explore the neurophysiological basis and phylogenetic relevance of these primitive reflexes.
Main Methods:
- Clinical observation and assessment of neonatal reflexes.
- Review of neurophysiological mechanisms underlying primitive reflexes.
- Discussion of phylogenetic and evolutionary perspectives on neonatal reflexes.
Main Results:
- Plantar and palmar grasp reflexes are significant indicators for detecting spasticity and other neurological conditions.
- The absence of the Moro reflex is highly diagnostic for various compromised neonatal conditions.
- Primitive reflexes appear to be mediated by spinal mechanisms under supraspinal control.
Conclusions:
- Primitive reflexes are essential tools for neonatal neurological evaluation.
- Understanding these reflexes aids in early diagnosis and management of developmental disorders.
- Further research is needed to fully elucidate the phylogenetic role and precise neural control of these reflexes.
Abstract:
The plantar grasp reflex is of great clinical significance, especially in terms of the detection of spasticity. The palmar grasp reflex also has diagnostic significance. This grasp reflex of the hands and feet is mediated by a spinal reflex mechanism, which appears to be under the regulatory control of nonprimary motor areas through the spinal interneurons. This reflex in human infants can be regarded as a rudiment of phylogenetic function. The absence of the Moro reflex during the neonatal period and early infancy is highly diagnostic, indicating a variety of compromised conditions. The center of the reflex is probably in the lower region of the pons to the medulla. The phylogenetic meaning of the reflex remains unclear. However, the hierarchical interrelation among these primitive reflexes seems to be essential for the arboreal life of monkey newborns, and the possible role of the Moro reflex in these newborns was discussed in relation to the interrelationship.
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