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Quantifying misclassification bias in cohort studies of vaccine efficacy
1PHLS Communicable Disease Surveillance Centre, London, U.K.
Statistics in Medicine
|November 1, 1990
Abstract:
A simple mathematical model is presented to quantify the bias due to misclassification in prospective cohort studies of vaccine efficacy. Limitations of methods based on quantifying misclassification in 2 x 2 tables are discussed. The model is applied to data from three examples of the design and analysis of studies of pertussis vaccine efficacy.