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07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas
Michael P Rethman1, William Carpenter, Ezra E W Cohen
1College of Dentistry, The Ohio State University, Columbus, USA.
Texas Dental Journal
|July 12, 2012
Summary
Dental screening can detect early oral cancers, but evidence is insufficient to prove it reduces mortality in asymptomatic patients. Clinicians should remain vigilant, especially for high-risk individuals.
Area of Science:
- Oral oncology
- Dental public health
- Evidence-based dentistry
Background:
- Clinical recommendations for oral cancer screening were developed by the American Dental Association Council on Scientific Affairs.
- The report evaluates the benefits and risks of screening for oral squamous cell carcinomas and adjunctive screening aids.
- Focus is on visualizing and detecting potentially malignant and malignant oral lesions.
Purpose of the Study:
- To provide evidence-based clinical recommendations on oral cancer screening.
- To assess the utility of visual and tactile examinations and adjunctive screening aids.
- To inform dental professionals about current evidence regarding oral cancer detection.
Main Methods:
- Systematic literature search of MEDLINE.
- Inclusion of 332 systematic reviews and 1,499 recent clinical studies.
- Selection of 5 systematic reviews and 4 clinical studies for developing recommendations.
Main Results:
- Visual and tactile screening may detect oral cancers at early stages.
- Insufficient evidence exists to confirm if screening alters disease-specific mortality in asymptomatic dental patients.
- The effectiveness of adjunctive screening aids requires further investigation.
Conclusions:
- Clinicians should maintain vigilance for potentially malignant lesions and early cancers during routine examinations.
- Particular attention is advised for patients with heavy tobacco or alcohol use.
- Further research on oral cancer screening methods and adjuncts is necessary.
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