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Related Experiment Video

Updated: May 20, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Do amniotic fluid leptin levels decrease in pregnancies with fetal trisomy 21?

A Demir¹, B Saatli, E Cagliyan

¹Department of Obstetrics and Gynecology, Elazıg Training and Research Hospital, Turkey. ahmet_demir77@hotmail.com

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology

|July 12, 2012

Summary

This study found no significant difference in amniotic fluid leptin levels between fetuses with Down syndrome (trisomy 21) and normal fetuses. These findings suggest leptin is not involved in Down syndrome

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Area of Science:

Perinatal Medicine
Genetics
Endocrinology

Background:

Down syndrome (trisomy 21) is a genetic disorder with complex fetal development.
Leptin is a hormone involved in various physiological processes, but its role in fetal development, particularly in trisomy 21, is not fully understood.

Purpose of the Study:

To investigate the potential correlation between amniotic fluid leptin levels and Down syndrome in the second trimester of pregnancy.
To determine if leptin could serve as a potential biomarker for Down syndrome.

Main Methods:

Retrospective analysis of 15 fetuses with Down syndrome and 48 controls with normal karyotype.
Quantification of second-trimester amniotic fluid leptin levels using enzyme-linked immunosorbent assay (ELISA).
Statistical evaluation of leptin levels using the Mann-Whitney U test.

Main Results:

Amniotic fluid leptin levels did not show a statistically significant difference between fetuses with Down syndrome and normal fetuses (p = 0.061).
Median leptin levels were 10.06 ng/ml for trisomy 21 fetuses and 14.53 ng/ml for normal fetuses.
The observed ranges for leptin levels were broad in both groups.

Conclusions:

Leptin levels in amniotic fluid do not appear to be altered in fetuses with trisomy 21.
This study excludes a significant role for leptin in the pathogenic processes of Down syndrome during the fetal period.
Leptin is unlikely to be a useful diagnostic tool for detecting Down syndrome in the second trimester.