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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Automated solid-phase synthesis of hyaluronan oligosaccharides
Marthe T C Walvoort1, Anne Geert Volbeda, Niels R M Reintjens
1Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands, and Ancora Pharmaceuticals , 1B Gill Street, Woburn, Massachusetts 01801, United States.
Abstract:
Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.
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